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The National Alliance for the Primary Prevention of Sharps Injuries (NAPPSI) is a group of health organizations, medical device manufacturers, healthcare professionals, and others working cooperatively to reduce sharps injuries by reducing the number of sharps in the workplace.

NAPPSI has been formed to further the primary prevention technologies and practices that reduce the number of healthcare workers who are victimized each year by medical sharps. An estimated 800,000 medical sharps injuries occur each year in healthcare facilities across the country. At risk is any healthcare worker who handles sharp devices or equipment such as lancets, suture needles, scalpels, or hypodermic needles.